A rejected mind led humanity to choose idolatry and the many gods of polytheism. So, God has turned humanity over to the limited functioning of its mind.
Paul said that God has turned humanity over to its appetites and its passions or strong negative moods. In the third handing over, God handed humanity over to its limited thinking.
28 And just as they did not see fit to personally know God any longer, God handed them over to a rejected mind, to do those things which are not proper,
29 being filled with all unrighteousness, wickedness, greed, evil; full of envy, murder, strife, deceit, malice; they are gossips,
30 slanderers, haters of God, insolent, arrogant, boastful, inventors of evil, disobedient to parents, (Rom 1:28-30)
A rejected mind led them to choose idolatry and the many gods of polytheism. So God has turned humanity over to the limited functioning of their minds. This is very similar to what the father of the prodigal son did. The prodigal son left the father's house and the father let the son experience the fruit of his poor choices. This display of God's wrath has love behind it. God is leaving humanity to its own insides so that it will flee back to the Gospel and the good Father in Heaven. This type of wrath is the background to the Gospel. We should emphasize this because it explains why God does not continually interfere in this world.